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訂購(gòu)信息
上海拜力生物科技公司
Tel:400-968-7988    021-33779008
DiscoverX MKP5, active 10 μg 14-779
品牌:Eurofins DiscoverX
貨號(hào):14-779
規(guī)格:14-779
貨期:DiscoverX
應(yīng)用: 點(diǎn)擊這里給我發(fā)消息  咨詢(xún)客服

品牌:DiscoverX 品名:MKP5, active 貨號(hào):14-779 規(guī)格:10 μg

商品詳情 參考文獻(xiàn) 相關(guān)資料

品牌:DiscoverX
品名:MKP5, active
貨號(hào):14-779  
規(guī)格:10 μg

簡(jiǎn)要說(shuō)明:

N-terminal 6His-tagged recombinant, human MKP5 amino acids 320-end. Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members ofthis family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.


產(chǎn)品詳情介紹:

Target
MKP5
Expression System
Expressed in E. coli
Application
Phosphatase Assay
Molecular Weight
20.6 kDa
Accession Number
NM_007207
Species
Human
Tag
6His
Purification Method
Ni2+/NTA-agarose
Content
Protein in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Storage
6 months at -70°C
Bulk Sizes
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