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品牌：List Labs 

貨號(hào)：191A

品名：List Labs Tetanus Toxoid from Clostridium tetani

中文名：破傷風(fēng)毒素

規(guī)格：25 ug

形式：lyophilized powder

儲(chǔ)存溫度：2-8°C

描述：

Tetanus toxin is a potent neurotoxin (150,000 Da) produced by the anaerobic bacterium Clostridium tetani. 1 Intact toxin derived from culture supernatants consists of two polypeptide chains connected through an interchain disulfide bond. The larger of the two polypeptides, heavy chain (100,000 Da), contains the toxin's binding and translocation domains. The smaller of the two polypeptides, light chain (50,000 Da), is a protease which cleaves synaptobrevin 2, also known as VAMP 2.  Synaptobrevin 2 is a presynaptic, vesicle membrane associated protein that, in the presence of calcium, forms a stable complex with two plasma membrane attached proteins, syntaxin and SNAP25. Complex formation initiates fusion of transmitter containing vesicles with the plasma membrane. If synaptobrevin 2 is cleaved by tetanus toxin, fusion is prevented, and neurotransmitter release is inhibited. Tetanus toxin prefere

注：產(chǎn)品僅用于研究目的，不得用于人體或作為診斷劑。